Guney, EvrenEhrenthal, JoachimHanne, Thomas2025-04-052025-04-0520252169-3536https://doi.org/10.1109/ACCESS.2025.3550788The Multi-Knapsack Problem (MKP) is a fundamental challenge in operations research and combinatorial optimization. Quantum computing introduces new possibilities for solving MKP using Quadratic Unconstrained Binary Optimization (QUBO) models. However, a key challenge in QUBO formulations is the selection of penalty parameters, which directly influence solution feasibility and algorithm performance. In this work, we develop QUBO formulations for two MKP variants-the Multidimensional Knapsack Problem (MDKP) and the Multiple Knapsack Problem (MUKP)-and provide an algebraic characterization of their penalty parameters. We systematically evaluate their impact through quantum simulation experiments and compare the performance of the two leading quantum optimization approaches: Quantum Approximate Optimization Algorithm (QAOA) and quantum annealing, alongside a state-of-the-art classical solver. Our results indicate that while classical solvers remain superior, careful tuning of penalty parameters has a strong impact on quantum optimization outcomes. QAOA is highly sensitive to parameter choices, whereas quantum annealing produces more stable results on small to mid-sized instances. Further, our results reveal that MDKP instances can maintain feasibility at penalty values below theoretical bounds, while MUKP instances show greater sensitivity to penalty reductions. Finally, we outline directions for future research in solving MKP, including adaptive penalty parameter tuning, hybrid quantum-classical approaches, and practical optimization strategies for QAOA, as well as real-hardware evaluations.eninfo:eu-repo/semantics/openAccessOptimizationQuantum ComputingLogic GatesQuantum AnnealingAnnealingQubitNoiseApproximation AlgorithmsTuningQuantum StateMulti-Dimensional Knapsack ProblemMultiple Knapsack ProblemQuadratic Unconstrained Binary OptimizationQuantum AnnealingQuantum Approximate Optimization AlgorithmPenalty ParametersArticle10.1109/ACCESS.2025.35507882-s2.0-105001091746Q2Q1470984708613WOS:001448323100029